Copa Libertadores
FIFA Region
CONMEBOL
Season
2021
Location
South America
Abbreviation
COPALIB
Summary
The 2021 Copa Libertadores is South America's premier club football tournament where top club teams (47 total) from all 10 CONMEBOL F/As (football associations) are represented. It is the equivalent of the UEFA Champions League. The 2021 winner will play in the 2022 Recopa Sudamericana against the winner of the 2021 Copa Sudamericana and in the 2021 FIFA Club World Cup.
Each F/A is given a minimum of 4 berths, while Argentina is given 6 berths and Brazil 7 berths. Defensa y Justicia (ARG1) won the 2020 Copa Sudamericana and Palmeiras (BRA1) won the 2020 Copa Libertadores, so both Argentina and Brazil received additional berths. Stage entry is based on cummulative historical relative performance of each F/A against the other F/As.
After the Group Stage, the 3rd place teams in each group enter the 2021 Copa Sudamericana Group Stage.
More Info...
2021 Copa Libertadores Berths
| F/A | COPALIB Teams | COPASUD Teams |
|---|---|---|
| Argentina | 7 | 6 |
| Boliva | 4 | 4 |
| Brazil | 8 | 6 |
| Chile | 4 | 4 |
| Colombia | 4 | 4 |
| Ecuador | 4 | 4 |
| Paraguay | 4 | 4 |
| Peru | 4 | 4 |
| Uruguay | 4 | 4 |
| Venezuela | 4 | 4 |
Competition Structure
| Stage | # Teams | New Teams Entering This Round | Teams From Previous Round | Format |
|---|---|---|---|---|
| First Stage | 6 |
| 3 sets of Home/Away matches, highest aggregate goals advances | |
| Second Stage | 16 |
| 3 winners from First Stage | 8 sets of Home/Away matches, highest aggregate goals advances |
| Third Stage | 8 | None | 8 winners from Second Stage | 4 sets of Home/Away matches, highest aggregate goals advances |
| Group | 32 |
| 4 winners from Third Stage | 8 groups of 4 with Home/Away matches against each team in group, top 2 teams with most points (win = 3 pts, draw = 1 pt) in each group advance |
| Round of 16 | 16 | None | 8 group winners, 8 group runners-up | 8 sets of Home/Away matches, highest aggregate goals advances |
| Quarterfinals | 8 | None | 8 winners from Round of 16 | 4 sets of Home/Away matches, highest aggregate goals advances |
| Semifinals | 4 | None | 4 winners from Quarterfinals | 2 sets of Home/Away matches, highest aggregate goals advances |
| Final | 2 | None | 2 winners from Semifinals | Home/Away matches, highest aggregate goals wins |
Final
| Date | Home | Status | Road | Venue | ||||
Sat - 27 Nov 2021
Semifinals
| Date | Home | Status | Road | Venue | ||||
| Aggregate | Palmeiras (BRA1) | 11 | Atlético MG (BRA1) |
| 21.09.21 |  | 00 | Atlético MG | Allianz Parque |
| 28.09.21 | | 11 | Palmeiras | Mineirão | ||
| Palmeiras advances w/more away goals (1-0). | ||||||
| Aggregate | Flamengo (BRA1) | 40 | Barcelona SC (ECU1) |
| 22.09.21 |  | 20 | Barcelona SC | Estádio do Maracanã |
| 29.09.21 | | 02 | Flamengo | Estadio Banco Pichincha |
Quarterfinals
| Date | Home | Status | Road | Venue | ||||
| Aggregate | São Paulo (BRA1) | 14 | Palmeiras (BRA1) |
| Aggregate | Club Olimpia (PAR1) | 29 | Flamengo (BRA1) |
| 11.08.21 |  | 14 | Flamengo | Estadio Manuel Ferreira |
| 18.08.21 | | 51 | Club Olimpia | Estádio Nacional Mané Garrincha |
| Aggregate | River Plate (ARG1) | 04 | Atlético MG (BRA1) |
| 11.08.21 |  | 01 | Atlético MG | Estadio Monumental Antonio Vespucio Liberti |
| 18.08.21 | | 30 | River Plate | Mineirão |
| Aggregate | Fluminense FC (BRA1) | 33 | Barcelona SC (ECU1) |
| 12.08.21 |  | 22 | Barcelona SC | Estádio do Maracanã |
| 19.08.21 | | 11 | Fluminense FC | Estadio Banco Pichincha | ||
| Barcelona SC advances w/more away goals (2-1). | ||||||
Round of 16
| Date | Home | Status | Road | Venue | ||||
| Aggregate | Boca Juniors (ARG1) | 13 | Atlético MG (BRA1) |
| 13.07.21 |  | 00 | Atlético MG | La Bombonera |
| 20.07.21 | | 31 | Boca Juniors | Mineirão |
| Aggregate | Cerro Porteño (PAR1) | 03 | Fluminense FC (BRA1) |
| 13.07.21 |  | 02 | Fluminense FC | Estadio General Pablo Rojas |
| 03.08.21 | | 10 | Cerro Porteño | Estádio do Maracanã |
| Aggregate | São Paulo (BRA1) | 42 | Racing Club (ARG1) |
| 13.07.21 |  | 11 | Racing Club | Estádio do Morumbi |
| 20.07.21 | | 13 | São Paulo | El Cilindro |
| Aggregate | CD Univ Católica (CHI1) | 02 | Palmeiras (BRA1) |
| 14.07.21 |  | 01 | Palmeiras | Estadio San Carlos de Apoquindo |
| 21.07.21 | | 10 | CD Univ Católica | Allianz Parque |
| Aggregate | Vélez Sarsfield (ARG1) | 23 | Barcelona SC (ECU1) |
| 14.07.21 |  | 10 | Barcelona SC | Estadio José Amalfitani |
| 21.07.21 | | 31 | Vélez Sarsfield | Estadio Banco Pichincha |
| Aggregate | Defensa y Justicia (ARG1) | 15 | Flamengo (BRA1) |
| 14.07.21 |  | 01 | Flamengo | Estadio Norberto Tomaghello |
| 21.07.21 | | 41 | Defensa y Justicia | Estádio do Maracanã |
| Aggregate | River Plate (ARG1) | 31 | Argentinos Juniors (ARG1) |
| 14.07.21 | | 11 | Argentinos Juniors | Estadio Monumental Antonio Vespucio Liberti |
| 21.07.21 | | 02 | River Plate | Estadio Diego Armando Maradona |
| Aggregate | Club Olimpia (PAR1) | 00 | Internacional (BRA1) |
| 15.07.21 | | 00 | Internacional | Estadio Manuel Ferreira |
| 22.07.21 | | 00 | Club Olimpia | Estádio Beira-Rio | ||
| Club Olimpia advances on PKs (5-4). | ||||||
Group Stage
| Group A | League | Home | Road | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| POS | MP | W - D - L | PTS | CPTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | |
| 1 | Palmeiras (BRA1) | 6 | 5 -0-1 | 15 | - | 20 | 7 | 13 | 3 | 2 -0-1 | 6 | 14 | 4 | 10 | 3 | 3 -0-0 | 9 | 6 | 3 | 3 |
| 2 | Defensa y Justicia (ARG1) | 6 | 2 -3-1 | 9 | - | 11 | 8 | 3 | 3 | 1 -1-1 | 4 | 5 | 3 | 2 | 3 | 1 -2-0 | 5 | 6 | 5 | 1 |
| 3 | CSD Independiente (ECU1) | 6 | 1 -2-3 | 5 | - | 8 | 11 | -3 | 3 | 1 -1-1 | 4 | 5 | 2 | 3 | 3 | 0 -1-2 | 1 | 3 | 9 | -6 |
| 4 | Universitario Deportes (PER1) | 6 | 1 -1-4 | 4 | - | 6 | 19 | -13 | 3 | 1 -1-1 | 4 | 6 | 6 | 0 | 3 | 0 -0-3 | 0 | 0 | 13 | -13 |
Round of 16 2021 COPASUD | ||||||||||||||||||||
| Date | Home | Status | Road | Venue | ||||
| 21.04.21 |  | 23 | Palmeiras | Estadio Monumental (Lima) |
 | 11 | Defensa y Justicia | Estadio Municipal Rumiñahui |
| 27.04.21 | | 50 | CSD Independiente | Allianz Parque |
| 28.04.21 | | 30 | Universitario Deportes | Estadio Norberto Tomaghello |
| 04.05.21 | | 12 | Palmeiras | Estadio Norberto Tomaghello |
| 05.05.21 | | 40 | Universitario Deportes | Estadio Rodrigo Paz Delgado |
| 11.05.21 | | 01 | Palmeiras | Estadio Rodrigo Paz Delgado |
| 12.05.21 | | 11 | Defensa y Justicia | Estadio Monumental (Lima) |
| 18.05.21 | | 34 | Defensa y Justicia | Allianz Parque |
| 32 | CSD Independiente | Estadio Monumental (Lima) |
| 27.05.21 | | 60 | Universitario Deportes | Allianz Parque |
| 11 | CSD Independiente | Estadio Norberto Tomaghello |
| Group B | League | Home | Road | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| POS | MP | W - D - L | PTS | CPTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | |
| 1 | Internacional (BRA1) | 6 | 3 -1-2 | 10 | - | 12 | 5 | 7 | 3 | 2 -1-0 | 7 | 10 | 1 | 9 | 3 | 1 -0-2 | 3 | 2 | 4 | -2 |
| 2 | Club Olimpia (PAR1) | 6 | 3 -0-3 | 9 | - | 13 | 14 | -1 | 3 | 2 -0-1 | 6 | 8 | 4 | 4 | 3 | 1 -0-2 | 3 | 5 | 10 | -5 |
| 3 | Deportivo Táchira FC (VEN1) | 6 | 3 -0-3 | 9 | - | 14 | 17 | -3 | 3 | 3 -0-0 | 9 | 12 | 5 | 7 | 3 | 0 -0-3 | 0 | 2 | 12 | -10 |
| 4 | Club Always Ready (BOL1) | 6 | 2 -1-3 | 7 | - | 8 | 11 | -3 | 3 | 2 -0-1 | 6 | 5 | 2 | 3 | 3 | 0 -1-2 | 1 | 3 | 9 | -6 |
Round of 16 2021 COPASUD | ||||||||||||||||||||
| Date | Home | Status | Road | Venue | ||||
| 20.04.21 |  | 32 | Club Olimpia | Estadio Polideportivo de Pueblo Nuevo |
 | 20 | Internacional | Estadio Hernando Siles |
| 27.04.21 | | 40 | Deportivo Táchira FC | Estádio Beira-Rio |
| 28.04.21 | | 21 | Club Always Ready | Estadio Manuel Ferreira |
| 05.05.21 | | 61 | Club Olimpia | Estádio Beira-Rio |
| 06.05.21 | | 20 | Deportivo Táchira FC | Estadio Hernando Siles |
| 11.05.21 | | 21 | Internacional | Estadio Polideportivo de Pueblo Nuevo |
| 13.05.21 | | 12 | Club Olimpia | Estadio Hernando Siles |
| 19.05.21 | | 72 | Club Always Ready | Estadio Polideportivo de Pueblo Nuevo |
| 20.05.21 | | 01 | Internacional | Estadio Manuel Ferreira |
| 26.05.21 | | 00 | Club Always Ready | Estádio Beira-Rio |
| 62 | Deportivo Táchira FC | Estadio Manuel Ferreira |
| Group C | League | Home | Road | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| POS | MP | W - D - L | PTS | CPTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | |
| 1 | Barcelona SC (ECU1) | 6 | 4 -1-1 | 13 | - | 10 | 3 | 7 | 3 | 3 -0-0 | 9 | 8 | 1 | 7 | 3 | 1 -1-1 | 4 | 2 | 2 | 0 |
| 2 | Boca Juniors (ARG1) | 6 | 3 -1-2 | 10 | - | 6 | 2 | 4 | 3 | 2 -1-0 | 7 | 5 | 0 | 5 | 3 | 1 -0-2 | 3 | 1 | 2 | -1 |
| 3 | Santos FC (BRA1) | 6 | 2 -0-4 | 6 | - | 8 | 9 | -1 | 3 | 2 -0-1 | 6 | 6 | 2 | 4 | 3 | 0 -0-3 | 0 | 2 | 7 | -5 |
| 4 | Club The Strongest (BOL1) | 6 | 2 -0-4 | 6 | - | 4 | 14 | -10 | 3 | 2 -0-1 | 6 | 4 | 2 | 2 | 3 | 0 -0-3 | 0 | 0 | 12 | -12 |
Round of 16 2021 COPASUD | ||||||||||||||||||||
| Date | Home | Status | Road | Venue | ||||
| 20.04.21 |  | 02 | Barcelona SC | Estádio Urbano Caldeira |
| 21.04.21 |  | 01 | Boca Juniors | Estadio Hernando Siles |
| 27.04.21 | | 20 | Santos FC | La Bombonera |
| 28.04.21 | | 40 | Club The Strongest | Estadio Banco Pichincha |
| 04.05.21 | | 50 | Club The Strongest | Estádio Urbano Caldeira |
| 10 | Boca Juniors | Estadio Banco Pichincha |
| 11.05.21 | | 20 | Barcelona SC | Estadio Hernando Siles |
| 10 | Boca Juniors | Estádio Urbano Caldeira |
| 18.05.21 | | 21 | Santos FC | Estadio Hernando Siles |
| 20.05.21 | | 00 | Barcelona SC | La Bombonera |
| 26.05.21 | | 30 | Club The Strongest | La Bombonera |
| 31 | Santos FC | Estadio Banco Pichincha |
| Group D | League | Home | Road | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| POS | MP | W - D - L | PTS | CPTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | |
| 1 | Fluminense FC (BRA1) | 6 | 3 -2-1 | 11 | - | 10 | 7 | 3 | 3 | 1 -1-1 | 4 | 4 | 4 | 0 | 3 | 2 -1-0 | 7 | 6 | 3 | 3 |
| 2 | River Plate (ARG1) | 6 | 2 -3-1 | 9 | - | 7 | 7 | 0 | 3 | 2 -0-1 | 6 | 5 | 5 | 0 | 3 | 0 -3-0 | 3 | 2 | 2 | 0 |
| 3 | Junior de Barranquilla (COL1) | 6 | 1 -4-1 | 7 | - | 6 | 6 | 0 | 3 | 0 -3-0 | 3 | 3 | 3 | 0 | 3 | 1 -1-1 | 4 | 3 | 3 | 0 |
| 4 | Independiente Santa Fe (COL1) | 6 | 0 -3-3 | 3 | - | 4 | 7 | -3 | 3 | 0 -2-1 | 2 | 1 | 2 | -1 | 3 | 0 -1-2 | 1 | 3 | 5 | -2 |
Round of 16 2021 COPASUD | ||||||||||||||||||||
| Date | Home | Status | Road | Venue | ||||
| 22.04.21 | | 11 | River Plate | Estádio do Maracanã |
 | 11 | Independiente Santa Fe | Estadio Metropolitano Roberto Meléndez |
| 28.04.21 | | 12 | Fluminense FC | Estadio Centenario de Armenia |
| 21 | Junior de Barranquilla | Estadio Monumental Antonio Vespucio Liberti |
| 06.05.21 | | 00 | River Plate | Estadio General Pablo Rojas |
| 11 | Fluminense | Estadio Banco Pichincha |
| 12.05.21 | | 21 | Independiente Santa Fe | Estádio do Maracanã |
| 11 | River Plate | Estadio Romelio Martínez |
| 18.05.21 | | 12 | Junior de Barranquilla | Estádio do Maracanã |
| 19.05.21 | | 21 | Independiente Santa Fe | Estadio Monumental Antonio Vespucio Liberti |
| 25.05.21 | | 13 | Fluminense FC | Estadio Monumental Antonio Vespucio Liberti |
| 00 | Junior de Barranquilla | Estadio Bellavista |
| Group E | League | Home | Road | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| POS | MP | W - D - L | PTS | CPTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | |
| 1 | Racing Club (ARG1) | 6 | 4 -2-0 | 14 | - | 9 | 2 | 7 | 3 | 2 -1-0 | 7 | 5 | 1 | 4 | 3 | 2 -1-0 | 7 | 4 | 1 | 3 |
| 2 | São Paulo (BRA1) | 6 | 3 -2-1 | 11 | - | 9 | 2 | 7 | 3 | 2 -0-1 | 6 | 5 | 1 | 4 | 3 | 1 -2-0 | 5 | 4 | 1 | 3 |
| 3 | Sporting Cristal (PER1) | 6 | 1 -1-4 | 4 | - | 3 | 10 | -7 | 3 | 1 -0-2 | 3 | 2 | 5 | -3 | 3 | 0 -1-2 | 1 | 1 | 5 | -4 |
| 4 | CA Rentistas (URU2) | 6 | 0 -3-3 | 3 | - | 2 | 9 | -7 | 3 | 0 -3-0 | 3 | 2 | 2 | 0 | 3 | 0 -0-3 | 0 | 0 | 7 | -7 |
Round of 16 2021 COPASUD | ||||||||||||||||||||
| Date | Home | Status | Road | Venue | ||||
| 20.04.21 |  | 03 | São Paulo | Estadio Nacional de Lima |
| 21.04.21 |  | 11 | Racing Club | Estadio Centenario (Montevideo) |
| 29.04.21 | | 21 | Sporting Cristal | El Cilindro |
| 20 | CA Rentistas | Estádio do Morumbi |
| 05.05.21 | | 00 | São Paulo | El Cilindro |
| 00 | Sporting Cristal | Estadio Centenario (Montevideo) |
| 11.05.21 | | 02 | Racing Club | Estadio Nacional de Lima |
| 12.05.21 | | 11 | São Paulo | Estadio Centenario (Montevideo) |
| 18.05.21 | | 01 | Racing Club | Estádio do Morumbi |
| 19.05.21 | | 20 | CA Rentistas | Estadio Nacional de Lima |
| 25.05.21 | | 30 | CA Rentistas | El Cilindro |
| 30 | Sporting Cristal | Estádio do Morumbi |
| Group F | League | Home | Road | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| POS | MP | W - D - L | PTS | CPTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | |
| 1 | Argentinos Juniors (ARG1) | 6 | 4 -0-2 | 12 | - | 7 | 3 | 4 | 3 | 2 -0-1 | 6 | 3 | 1 | 2 | 3 | 2 -0-1 | 6 | 4 | 2 | 2 |
| 2 | CD Univ Católica (CHI1) | 6 | 3 -0-3 | 9 | - | 6 | 6 | 0 | 3 | 2 -0-1 | 6 | 5 | 3 | 2 | 3 | 1 -0-2 | 3 | 1 | 3 | -2 |
| 3 | Nacional (URU1) | 6 | 2 -2-2 | 8 | - | 8 | 9 | -1 | 3 | 2 -1-0 | 7 | 7 | 4 | 3 | 3 | 0 -1-2 | 1 | 1 | 5 | -4 |
| 4 | Atlético Nacional (COL1) | 6 | 1 -2-3 | 5 | - | 6 | 9 | -3 | 3 | 1 -1-1 | 4 | 2 | 2 | 0 | 3 | 0 -1-2 | 1 | 4 | 7 | -3 |
Round of 16 2021 COPASUD | ||||||||||||||||||||
| Date | Home | Status | Road | Venue | ||||
| 20.04.21 | | 20 | Nacional | Estadio Diego Armando Maradona |
| 22.04.21 |  | 20 | CD Univ Católica | Estadio Atanasio Giradot |
| 28.04.21 | | 44 | Atlético Nacional | Estadio Gran Parque Central |
| 29.04.21 | | 02 | Argentinos Juniors | Estadio San Carlos de Apoquindo |
| 05.05.21 | | 31 | Nacional | Estadio San Carlos de Apoquindo |
| 06.05.21 | | 02 | Argentinos Juniors | Estadio Manuel Ferreira |
| 12.05.21 | | 01 | CD Univ Católica | Estadio Diego Armando Maradona |
| 00 | Nacional | Estadio Hernán Ramírez Villegas |
| 18.05.21 | | 10 | CD Univ Católica | Estadio Gran Parque Central |
| 20.05.21 | | 10 | Atlético Nacional | Estadio Diego Armando Maradona |
| 26.05.21 | | 20 | Argentinos Juniors | Estadio Gran Parque Central |
| 20 | Atlético Nacional | Estadio San Carlos de Apoquindo |
| Group G | League | Home | Road | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| POS | MP | W - D - L | PTS | CPTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | |
| 1 | Flamengo (BRA1) | 6 | 3 -3-0 | 12 | - | 14 | 9 | 5 | 3 | 1 -2-0 | 5 | 6 | 3 | 3 | 3 | 2 -1-0 | 7 | 8 | 6 | 2 |
| 2 | Vélez Sarsfield (ARG1) | 6 | 3 -1-2 | 10 | - | 10 | 8 | 2 | 3 | 2 -0-1 | 6 | 7 | 5 | 2 | 3 | 1 -1-1 | 4 | 3 | 3 | 0 |
| 3 | LDU Quito (ECU1) | 6 | 2 -2-2 | 8 | - | 15 | 13 | 2 | 3 | 2 -0-1 | 6 | 10 | 6 | 4 | 3 | 0 -2-1 | 2 | 5 | 7 | -2 |
| 4 | CD Unión La Calera (CHI1) | 6 | 0 -2-4 | 2 | - | 8 | 17 | -9 | 3 | 0 -2-1 | 2 | 4 | 6 | -2 | 3 | 0 -0-3 | 0 | 4 | 11 | -7 |
Round of 16 2021 COPASUD | ||||||||||||||||||||
| Date | Home | Status | Road | Venue | ||||
| 20.04.21 | | 23 | Flamengo | Estadio José Amalfitani |
| 21.04.21 |  | 22 | LDU Quito | Estadio Municipal Nicolás Chahuán |
| 27.04.21 | | 41 | CD Unión La Calera | Estádio do Maracanã |
| 31 | Vélez Sarsfield | Estadio Rodrigo Paz Delgado |
| 04.05.21 | | 02 | Velez Sarsfield | Estadio Municipal Nicolás Chahuán |
| 11.05.21 | | 22 | Flamengo | Estadio Municipal Nicolás Chahuán |
| 13.05.21 | | 31 | LDU Quito | Estadio José Amalfitani |
| 19.05.21 | | 21 | CD Unión La Calera | Estadio José Amalfitani |
| 27.05.21 | | 52 | CD Unión La Calera | Estadio Rodrigo Paz Delgado |
| 00 | Vélez Sarsfield | Estádio do Maracanã |
| Group H | League | Home | Road | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| POS | MP | W - D - L | PTS | CPTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | |
| 1 | Atlético MG (BRA1) | 6 | 5 -1-0 | 16 | - | 15 | 3 | 12 | 3 | 3 -0-0 | 9 | 10 | 1 | 9 | 3 | 2 -1-0 | 7 | 5 | 2 | 3 |
| 2 | Cerro Porteño (PAR1) | 6 | 3 -1-2 | 10 | - | 4 | 5 | -1 | 3 | 1 -1-1 | 4 | 1 | 1 | 0 | 3 | 2 -0-1 | 6 | 3 | 4 | -1 |
| 3 | América de Cali (COL1) | 6 | 1 -1-4 | 4 | - | 5 | 9 | -4 | 3 | 1 -0-2 | 3 | 4 | 6 | -2 | 3 | 0 -1-2 | 1 | 1 | 3 | -2 |
| 4 | Deportivo La Guaira (VEN1) | 6 | 0 -3-3 | 3 | - | 2 | 9 | -7 | 3 | 0 -2-1 | 2 | 1 | 2 | -1 | 3 | 0 -1-2 | 1 | 1 | 7 | -6 |
Round of 16 2021 COPASUD | ||||||||||||||||||||
| Date | Home | Status | Road | Venue | ||||
| 21.04.21 |  | 11 | Atlético MG | Estadio Olímpico de la UCV |
 | 02 | Cerro Porteño | Estadio Olímpico Pascual Guerrero |
| 27.04.21 | | 21 | América de Cali | Mineirão |
| 28.04.21 | | 00 | Deportivo La Guaira | Estadio General Pablo Rojas |
| 04.05.21 | | 40 | Cerro Porteño | Mineirão |
| 06.05.21 | | 00 | América de Cali | Estadio Olímpico de la UCV |
| 12.05.21 | | 01 | Cerro Porteño | Estadio Olímpico de la UCV |
| 13.05.21 | | 13 | Atlético MG | Estadio Romelio Martínez |
| 19.05.21 | | 01 | Atlético MG | Estadio General Pablo Rojas |
| 31 | Deportivo La Guaira | Estadio Ramón Tahuichi Aguilera |
| 25.05.21 | | 40 | Deportivo La Guaira | Mineirão |
| 10 | América de Cali | Estadio General Pablo Rojas |
3rd Round
| Date | Home | Status | Road | Venue | ||||
| Aggregate | San Lorenzo (ARG1) | 35 | Santos FC (BRA1) |
| 06.04.21 |  | 13 | Santos FC | Estadio Pedro Bidegain |
| 13.04.21 | | 22 | San Lorenzo | Estádio Nacional Mané Garrincha |
| Aggregate | Club Libertad (PAR1) | 24 | Atlético Nacional (COL1) |
| 07.04.21 |  | 10 | Atlético Nacional | Estadio Defensores del Chaco (Asunción) |
| 14.04.21 | | 41 | Club Libertad | Estadio Atanasio Giradot |
| Aggregate | FC Bolívar (BOL1) | 24 | Junior de Barranquilla (COL1) |
| 08.04.21 |  | 21 | Junior de Barranquilla | Estadio Hernando Siles |
| 15.04.21 | | 30 | FC Bolívar | Estadio Metropolitano Roberto Meléndez |
| Aggregate | CSD Independiente (ECU1) | 42 | Grêmio (BRA1) |
| 09.04.21 | | 21 | Grêmio | Estadio Rodrigo Paz Delgado |
| 14.04.21 | | 12 | CSD Independiente | Arena do Grêmio |
2nd Round
| Date | Home | Status | Road | Venue | ||||
| Aggregate | Wanderers FC (URU1) | 15 | FC Bolívar (BOL1) |
| 09.03.21 |  | 10 | FC Bolívar | Estadio Parque Alfredo Victor Viera |
| 16.03.21 | | 50 | Wanderers FC | Estadio Hernando Siles |
| Aggregate | Santos FC (BRA1) | 32 | CD Lara (VEN1) |
| Aggregate | Club Unión Española (CHI1) | 36 | CSD Independiente (ECU1) |
| 09.03.21 |  | 10 | CSD Independiente | Estadio Santa Laura |
| 16.03.21 | | 62 | Club Unión Española | Estadio Rodrigo Paz Delgado |
| Aggregate | CD Univ Católica (ECU1) | 23 | Club Libertad (PAR1) |
| 10.03.21 | | 01 | Club Libertad | Estadio Olímpico Atahualpa |
| 17.03.21 | | 22 | CD Univ Católica | Estadio Defensores del Chaco (Asunción) |
| Aggregate | Caracas FC (VEN1) | 25 | Junior de Barranquilla (COL1) |
| 10.03.21 |  | 12 | Junior de Barranquilla | Estadio Olímpico de la UCV |
| 17.03.21 | | 31 | Caracas FC | Estadio Metropolitano Roberto Meléndez |
| Aggregate | Club Univ de Chile (CHI1) | 13 | San Lorenzo (ARG1) |
| 10.03.21 |  | 11 | San Lorenzo | Estadio Nacional Julio Martínez Prádanos |
| 17.03.21 | | 20 | Club Univ de Chile | Estadio Pedro Bidegain |
| Aggregate | Grêmio (BRA1) | 82 | Ayacucho FC (PER1) |
| 10.03.21 | | 61 | Ayacucho FC | Arena do Grêmio |
| 16.03.21 | | 12 | Grêmio | Estadio Olímpico Atahualpa |
| Aggregate | Club Guaraní (PAR1) | 05 | Atlético Nacional (COL1) |
| 11.03.21 |  | 02 | Atlético Nacional | Estadio Defensores del Chaco (Asunción) |
| 18.03.21 | | 30 | Club Guaraní | Estadio Atanasio Giradot |
1st Round
| Date | Home | Status | Road | Venue | ||||
| Aggregate | Liverpool FC (URU1) | 24 | CD Univ Católica (ECU1) |
| 23.02.21 |  | 21 | CD Univ Católica | Estadio Parque Alfredo Victor Viera |
| 02.03.21 | | 30 | Liverpool FC | Estadio Olímpico Atahualpa |
| Aggregate | Univ César Vallejo (PER1) | 02 | Caracas FC (VEN1) |
| 24.02.21 |  | 00 | Caracas FC | Estadio Mansiche |
| 03.03.21 | | 20 | Univ César Vallejo | Estadio Olímpico de la UCV |
| Aggregate | Royal Pari FC (BOL1) | 25 | Club Guaraní (PAR1) |
| 24.02.21 |  | 14 | Club Guaraní | Estadio Ramón Tahuichi Aguilera |
| 03.03.21 | | 11 | Royal Pari FC | Estadio Luís Alfonso Giagni |