Each MEX1 team plays Home-Away matches with the other 17 MEX1 teams once in the 2024 Torneo Apertura (17 matches) and once in the 2025 Torneo Clausura (17 matches) for a total of 34 league matches per team. Table ranking ties are broken by (1) goal difference, (2) goals scored, (3) head-to-head results between tied teams, (4) away goals scored, (5) highest relegation coefficient, then (6) Fair Play points.

At the end of each torneo, the top four teams advance to the La Liguilla (the playoffs) Quarterfinals, and the 5th through 12th place teams advance to the Reclasificación. In the Reclasificación, 5th place plays 12th place, 6th place plays 11th place, 7th place plays 10th place, and 8th place plays 9th place in a single match playoff at the higher seed's home venue. If a match is tied after regulation time, the teams advance to a best of 5 penalty shoot-out. The winners play in Home-Away highest aggregate score advances Quarterfinals. The four advancing teams play in a Home-Away highest aggregate score advances Semifinals. The two Semifinal winners advance to the Finals with the winner becoming the torneo champion. All Torneo Finalists advance to the 2025 CNCFCL.

As of the 2020-2021 MEX1 season, promotion/relegation with the MEX2 was suspended. Instead, teams paid fines (used for the development of MEX2 teams) based on their position in the 2024-2025 MEX1 Coefficient Table.